Tuesday, May 25, 2021

Morgan Levine: Yale School of Medicine


We are all used to feeling younger than our years and occasionally older than our birthdate would suggest.  In effect, we have two ages - chronological and biological. Chronological age simply states the number of years that we have been alive, whereas biological age is measure of how well our bodies are performing, in relation to the rest of the population.  So how it is determined?  

LLAMA host Peter Bowes delved into the science with Elysium Health, which has developed Index, a DNA test that tracks how fast we have been aging, based on our epigenome, which regulates the way genes work.  

In this episode, Peter meets Dr. Morgan Levine, an assistant professor of pathology at Yale School of Medicine and an advisor to Elysium Health. They discuss the background to Index, its use of epigenetic clocks to put a number to our biological age, as well as the test's accuracy and implications for healthy living.   

Recorded: April 21, 2021 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:
  • Defining biological age and chronological age. 
  • Age as a risk factor for death and disease
  • Having an older parent and developing an interest in aging 
  • A lack of consensus over what exactly is meant by aging.
  • How much of aging can be defined as damage to the body, at a cellular level, as we grow older?
  • How do we measure biological age?  
  • Genes, genomes and the epigenome.
  • Developing systems that determine biological age based on epigenetic clocks.
  • Exploring the Index epigenetic, at-home saliva test, to determine biological age.    
  • Privacy concerns related to sharing personal medical information.  
  • Revealing Peter's biological versus chronological age. What does it mean? 
  • Interpreting the test results and taking action based on the findings.
  • Does the test reveal information specific to potential medical conditions?
  • How do doctors - primary care physicians - respond to the information gleaned from such tests? 
  • The paradigm shift from disease treatment to interventions that delay illness. 
  • Lifestyle interventions that promote a long, healthy life.  
  • The reliability of biological age tests. Do repeat tests over a short space of time generate the same results? 
  • To what extent do results vary between young and older people? 
  • Lifespan and healthspan aspirations. 
Disclosure:  For review purposes, Elysium Health provided Peter Bowes with an Index test kit, free of charge.

This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Wednesday, May 19, 2021

Daniel Kennedy: Filmmaker



Some of the world's healthiest people spend little or no time pondering their propensity to live a long life.  They just do it. Their lifestyles are a model for longevity. There is much we can learn from these vibrant populations, in counties such as Italy, India, Japan, and (even) parts of the United States.  In this episode of the LLAMA podcast with Peter Bowes, filmmaker Daniel Kennedy discusses his quest to better understand global food and ancient healing traditions. Daniel's documentary series, Healthy Long Life, is an exploratory journey around the globe and considers the discrepancy between lifespan and healthspan; he asks why, for many people, the final years of life are spent in sickness and pain and shares observations about spirituality, mealtime traditions and chronic diseases. 

Recorded: April 19, 2021 | Read a transcript and show notes at the LLAMA podcast website.

Topics covered in this interview include:
  • Filming Healthy, Long Life over four years and Daniel's motivation behind the project 
  • Lifespan vs healthspan and what it means for our children and grandchildren
  • Are chronic diseases pre-determined?  Searching for answers. 
  • Deriving inspiration from people with cancer to help others avoid the disease
  • Meeting physicians who use plants as medicine, including T. Colin Campbell, the author of the China Project 
  • Pinpointing the world's longevity hotspots and learning from ancient healing traditions 
  • Fighting illness or promoting health? 
  • Plant based diets and the risk of contracting cancer
  • Science, spirituality, food and faith 
  • The long lives of Seventh Day Adventists from Loma Linda, California
  • The idea that "genetics may load the gun but it's diet and lifestyle that pull the trigger."
  • The relative benefits of a healthy dietary regime and a life full of physical activity. 
  • Is there a French paradox - wine, cheese, butter and good health? 
  • Portion size and caloric restriction.
This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Wednesday, May 12, 2021

Sandra Kaufmann: Setting the bar high to stop aging


The science of aging is so infinitely fascinating that Dr. Sandra Kaufmann decided to immerse herself in the field, as a hobby. A pediatric anesthesiologist from Florida, Dr. Kaufmann, is also an athlete who manages to fit swimming, running and rock climbing around her busy hospital schedule.  Determined to enjoy physical activity for as long as possible, she decided to carry out an extensive review of the scientific literature, to better understand our bodies as we grow old.  She focussed on the mechanisms of aging at a cellular level and set out to sort fact from fiction when it comes to the substances or interventions that might help us age more slowly.  The result is, The Kaufmann Protocol: Why We Age and How to Stop It, a book in which she sets out seven key tenets to maintaining optimum health. In this LLAMA podcast conversation, with Peter Bowes, Dr Kaufmann  explains everything from the importance of mitochondrial health and the maintenance of metabolic pathways, to her live and let live attitude towards eating a donut a day. 

Recorded: April 13, 2021 | Read a transcript and show notes at the LLAMA podcast website.

In this interview we cover:
  • Setting the bar high to "overcome all aging"
  • The most ornate out-of-control hobby anybody can have
  • A light-bulb moment having off a cliff. 
  • Is it selfish to focus on the science of 'stopping' aging?
  • Becoming a human guinea pig to try to figure out why cells age. 
  • Nurturing the seven protocols
  • Debunking myths - or ideas behind grandma's remedies - about interventions to slow down the aging process
  • Junk food, including a donut a day.  Really? 
  • Being an exercise junkie
  • Biohacking: striving to improve what we are, but is the term realistic? 
  • Feeling like a teenager at 52
This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic - and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Wednesday, May 5, 2021

Simone Gibertoni & Adrian Heini: Clinique La Prairie

 


Embracing science and a holistic approach to living a healthier life, has been a hallmark of the Swiss spa-clinic, Clinique La Prairie (CLP), for the past ninety years. Known for its signature revitalizing therapy, the clinic opened in 1931, under the guidance of  Dr Paul Niehans, an early expert in the field. Today, CLP melds cutting edge technology with a mission to help people optimize their healthspan, though advanced clinical and wellness programs. The LLAMA podcast is teaming up with CLP to discuss the big issues surrounding human longevity. In this episode, Peter Bowes is joined by C.E.O. Simone Gibertoni and Medical Director, Dr. Adrian Heini.  In a wide-ranging conversation they cover the clinic's history, scientific developments, including Epigenetic screening, and the future of wellbeing as a priority in the post-Covid world. 


Recorded: April 20, 2021 | Read a transcript and show notes at the LLAMA podcast website.
  • Clinique La Prairie's 90-year legacy
  • The history of a medical spa that melds science and luxury relaxation 
  • The scientific gatekeepers monitoring the science behind health and wellness programs 
  • Using natural tools to curate a holistic approach to living better and longer
  • Developments in genetics and epigenetic tests to reveal predispositions to certain conditions
  • Tailored  programs to focus on conditions such as oxidative stress and inflammation
  • Plants, herbs and fatty acid profiles
  • The lifestyle traits that influence longevity
  • Personalized healthy living programs and the four pillars for longevity
  • Changing lives and following up to ensure long-term health
  • Why there is no "magic pill"
  • Mindfulness, meditation and bespoke physical exercise modifications 
  • The eye-opening impact of Covid on the business of wellness and the long term implications for healthcare
  • The lasting impact of a week's intensive therapies?
  • Implementing  long-term health programs though CLP hubs around the world. 
  • The importance of lifestyle changes and work/life balance. 
  • Morning routines and daily health. 
  • Taking the long view and imagining the wellness conversation for decades to come. 

This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic - and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.