David Marcinek: Biologist

Muscle endurance can be improved, in older adults, without physical exercise, according to the results of a new clinical trial.  Scientists in the US and Switzerland say their research suggests supplementation with a gut metabolite, known as urolithin A, may counteract age-associated muscle decline.  This is significant as a potential intervention that could slow the onset of frailty in older people, and prolong healthspan.   

The study, sponsored by the Swiss life science company, Amazentis  (also sponsors of this podcast), was conduced at the University of Washington Medical Center and the Fred Hutchinson Cancer Research Center in Seattle.  It was designed to test the hypothesis that long-term supplementation with Mitopure, a highly pure, synthetic form of urolithin A, would improve mitochondrial function and muscle performance in older adults.   

In this Live Long and Master Aging (LLAMA) podcast interview, the study's principal investigator, Prof. David Marcinek, explains the findings and why he believes they could be especially beneficial for older people who are  unable to exercise.  We also delve into the importance of mitochondrial health and why the so-called powerhouses of our cells play such a pivotal role in our ability to thrive and enjoy a long life. 

Interview recorded: January 12, 2022 | Read a transcript and show notes at the LLAMA website.

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DoNotAge.org is offering listeners to LLAMA a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more. Use the code LLAMA at checkout.  Any health queries can be answered by emailing the team at hello@donotage.org

Affiliation disclosure: The LLAMA podcast receives a small commission when you use the code LLAMA for purchases at DoNotAge.org.  It helps to cover production costs and ensures that our interviews remain free for all to listen.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Alan Graves: Entrepreneur

There are myriad lifestyle, dietary and exercise interventions that could lead to a longer healthspan and compressed morbidity.  Preventing chronic disease, as we age, is crucial but longevity science is also focused on shorter terms goals, such as staying physically and mentally healthy, today and tomorrow. 
Alan Graves is the CEO of Do Not Age, a UK-based longevity research company, which has the stated mission of extending healthy lifespan for as many people as possible. 

In this LLAMA podcast, Alan explains why he promotes a combination of lifestyle interventions, which are free to implement, along with targeted supplementation, to optimize wellbeing.  We delve into one of the hottest topics in the longevity field – the importance of NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every cell of the body and critical to hundreds of metabolic processes.  

Do Not Age’s flagship product is NMN, an NAD+ activator, which according to clinical studies, increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.

Interview recorded: January 6, 2022 | Read a transcript at the LLAMA website.

DoNotAge.org is offering listeners to LLAMA a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more. Use the code LLAMA at checkout.  Any health queries can be answered by emailing the team at hello@donotage.org

Affiliation disclosure: The podcast receives a small commission when you use the code LLAMA for purchases at DoNotAge.org.  It helps to cover production costs and ensures that our interviews remain free for all to listen.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Sergey Young: Investor

Longevity science has been moving at breakneck speed in recent years, reinforcing the view of some innovators that we are on the cusp of a 200-year lifespan.  Whether it be longevity in a pill, artificial organs or gene therapy to cure diseases, recent breakthroughs suggest many of us already have the tools needed to live longer and better.  Sergey Young is a longevity investor and visionary with a mission to extend healthy lifespans of at least one billion people. He founded the Longevity Vision Fund to accelerate life extension through technological innovations and recently published his book, The Science and Technology of Growing Young.  In this LLAMA podcast interview, Sergey explores his passion for the emerging science and explains why he believes that optimizing healthspan  – extending our healthy years – is within the reach everyone.  Sergey seeks, with pragmatism, to energize the aging process, celebrating what he calls the “the near horizon of longevity innovations.”

Interview recorded: October 20, 2021 | Read a transcript at the LLAMA website.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.