Sunday, January 23, 2022

David Marcinek: Biologist

Muscle endurance can be improved, in older adults, without physical exercise, according to the results of a new clinical trial.  Scientists in the US and Switzerland say their research suggests supplementation with a gut metabolite, known as urolithin A, may counteract age-associated muscle decline.  This is significant as a potential intervention that could slow the onset of frailty in older people, and prolong healthspan.   

The study, sponsored by the Swiss life science company, Amazentis  (also sponsors of this podcast), was conduced at the University of Washington Medical Center and the Fred Hutchinson Cancer Research Center in Seattle.  It was designed to test the hypothesis that long-term supplementation with Mitopure, a highly pure, synthetic form of urolithin A, would improve mitochondrial function and muscle performance in older adults.   

In this Live Long and Master Aging (LLAMA) podcast interview, the study's principal investigator, Prof. David Marcinek, explains the findings and why he believes they could be especially beneficial for older people who are  unable to exercise.  We also delve into the importance of mitochondrial health and why the so-called powerhouses of our cells play such a pivotal role in our ability to thrive and enjoy a long life. 

Interview recorded: January 12, 2022 | Read a transcript and show notes at the LLAMA website.

----------------- is offering listeners to LLAMA a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more. Use the code LLAMA at checkout.  Any health queries can be answered by emailing the team at

Affiliation disclosure: The LLAMA podcast receives a small commission when you use the code LLAMA for purchases at  It helps to cover production costs and ensures that our interviews remain free for all to listen.

The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

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